Evaluation Of Squamous Cell Carcinoma Research Articles

18F-FDG PET/CT in evaluation of squamous cell carcinoma.

Squamous cell carcinomas (SCC) are a number of different types of cancer that result from squamous cells. These cells form on the surface of the skin, on the lining of the respiratory and digestive tracts etc. To evaluate SCC and frequencies of their localizations based on the findings of fluorine-18-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT). This study included 343 consecutive patients with SCC who were sent for the 18F-FDG PET/CT. Inclusion criteria were: Pathohistologically verified SCC; absence of malignancy of any other localization, as well as absence of infection; and glycemia ≤11mmol/L. The pathological findings on 18F-FDG PET/CT were present in 86% of patients. There was statistically significant difference in the finding of 18F-FDG PET/CT in relation to gender (P>0.006). The disease was more often present in women. The most common localizations of disease were: lungs (70%), vagina/cervix (18%), gastrointestinal tract (18%), head and neck (5%). Highest maximum standardized uptake value (SUVmax) levels were seen in the lungs 11.78±8.38, vagina/cervix 11.21±8.10, and head and neck area 6.32±3.96. Fluorine-18-FDG PET/CT can be informative in evaluation of SCC. Disease is present usually in women, although it is the same pathohistological type of disease, different organs accumulate this radioactive contrast differently.

High-risk human papillomavirus testing in cytology aspiration samples from the head and neck part 2: a survey of the American Society of Cytopathology community.

High-risk human papillomavirus (HR-HPV) status is critical in the diagnosis of oropharyngeal squamous cell carcinoma, informing prognosis and choice of therapy. HR-HPV status additionally plays a key role in the evaluation of squamous cell carcinoma of unknown origin metastatic to cervical lymph nodes. Thus, HR-HPV testing of fine needle aspirate (FNA) specimens from the head and neck is invaluable for accurate diagnosis, prognostication, and treatment planning. American Society of Cytopathology members were surveyed to understand the current state of HR-HPV testing on FNA samples from the head and neck. The survey focused on 3 main topic areas: practice setting of respondents, methods of collection and processing of aspirate specimens for HR-HPV testing, and validation of HR-HPV testing methodologies on aspirate samples. The survey reveals that laboratories employ various methods to detect HR-HPV in FNA samples, most commonly p16 immunohistochemical staining of cell block sections. Although some laboratories have independently validated their HR-HPV detection method, such validation is not universal. Finally, not all respondents currently have HR-HPV testing available, but approximately half of those without a testing method desire to make HR-HPV testing of FNA samples available. Survey responses highlight that various testing modalities are utilized for HR-HPV detection in aspirate samples. However, internal laboratory validation of HR-HPV testing for FNA specimens is not ubiquitous despite professional society recommendations.

Multidetector computed tomography imaging of squamous cell carcinoma of buccal mucosa

<p>This study aims at describing the role of multidetector computed tomography (MDCT) and CT imaging findings in evaluation of squamous cell carcinoma of buccal mucosa and its staging. Retrospective study of 40 patients who underwent MDCT and were histopathogically proven case of squamous cell carcinoma (SCC) of buccal mucosa patients were included in the study. Plain, arterial, venous phase and puff cheek CT cuts were taken from base of skull till clavicle. The imaging findings in squamous cell carcinoma (SCC) of the oral cavity allow the radiologist to accurately determine the extent and staging of disease thereby help clinicians plan appropriate treatment. 40 such patients were done in which majority of them are male patients-27 as compared to female patients-13. Among these 40 patients, 20 patients had stage IVB cancer, 13 patients had stage IVA, 5 patients had stage II and 2 patients had stage I cancer. No patient included in our study had stage III.  Patients’ recovery will depend on how early the cancer is found and staging gives an idea of patients’ possible outcomes. MDCT is non-invasive and cost-effective investigation which helps in evaluating squamous cell carcinoma of buccal mucosa and determines its stage of buccal cancer and guide the therapy accordingly.</p>

Radiomics of apparent diffusion coefficient maps to predict histologic grade in squamous cell carcinoma of the oral tongue and floor of mouth: a preliminary study.

Histologic grade assessment plays an important part in the clinical decision making and prognostic evaluation of squamous cell carcinoma (SCC) of the oral tongue and floor of mouth (FOM). To assess the value of apparent diffusion coefficient (ADC)-based radiomics in discriminating between low- and high-grade SCC of the oral tongue and FOM. We included data from 88 patients (training cohort: n = 59; testing cohort: n = 29) who underwent diffusion-weighted imaging with a 3.0-T magnetic resonance imaging scanner before treatment. A total of 526 radiomics features were extracted from ADC maps to construct a radiomics signature with least absolute shrinkage and selection operator logistic regression. Receiver operating characteristic curves and areas under the curve (AUCs) were used to evaluate the performance of radiomic signature. Five features were selected to construct the radiomics signature for predicting histologic grade. The ADC-based radiomics signature performed well for discriminating between low- and high-grade tumors, with AUCs of 0.83 in both cohorts. Based on the cut-off value of the training cohort, the radiomics signature achieved accuracies of 0.78 and 0.79, sensitivities of 0.65 and 0.71, and specificities of 0.85 and 0.82 in the training and testing cohorts, respectively. ADC-based radiomics can be a useful and promising non-invasive method for predicting histologic grade of SCC of the oral tongue and FOM.

Toluidine Blue and Hematoxylin and Eosin Stains are Comparable in Evaluating Squamous Cell Carcinoma During Mohs

Histologic examination of tissue is the foundation of Mohs micrographic surgery because determination of surgical margins influences whether additional tissue will be taken. Currently, there is no large focused study comparing toluidine blue (TB) and hematoxylin and eosin (H&E) stains in the evaluation of squamous cell carcinoma (SCC). This study evaluates whether TB and H&E are comparable in assessing the presence of tumor in frozen sections of SCC. One hundred eighty-six randomized slides representing 93 tissue pieces from 36 tumors were examined by 3 Mohs surgeons (1 Accreditation Council for Graduate Medical Education fellow and 2 fellowship-trained surgeons) and compared using a template that documented the presence and location of tumor on the slides. The evaluation of SCC with H&E and TB stains was highly concordant, with concordant identification of SCC in 96%, 96%, and 94% of tissue layers among the 3 Mohs surgeons ARS, LHG, and AK-A, respectively. Toluidine blue and H&E stains are statistically similar in their ability to detect SCC and guide Mohs surgical decision-making.

Staging studies for evaluation of squamous cell carcinoma. Staging of left temporal squamous cell carcinoma with PET-CT.

Primary hyperoxaluria is a rare congenital disorder of abnormal glyoxylate metabolism with resultant over-accumulation of oxalate, which then binds with calcium and precipitates in the kidneys, resulting in nephrocalcinosis and nephrourolithiasis. As renal function worsens, patients develop systemic oxalosis with calcium oxalate deposition in the soft tissues, musculoskeletal system, cardiovascular system, central nervous system, and eyes [1–5]. There are three common types of primary hyperoxaluria (types I–III). Type I is the most common and severe and involves a mutation in the alanine glyoxylate aminotransferase (AGT) enzyme causing overproduction of oxalate glyoxylate [1]. Type II results from deficiency of glyoxylate reductase and hydroxypyruvate reductase (GRHPR), which results in overproduction of oxalate and L-glyceric aciduria [1, 5]. Type III results from mutation in 4-hydroxy-2oxoglutarate aldolase (HOGA) and is the least aggressive hyperoxaluria type, with most patients not progressing to end-stage renal disease (ESRD) [1]. Imaging findings in primary hyperoxaluria vary depending on patient age and renal function [2–6]. Prior to renal function impairment, imaging is frequently normal. As renal failure develops, cortical nephrocalcinosis and nephrourolithiasis will be seen (Fig. 1). Calcium oxalate subsequently deposits in soft tissues, tendons, and joint capsules, with joint effusions and nodular-appearing tumoral calcinosis (especially in periarticular regions, which can cause erosive arthropathy) [2–6]. As ESRD develops toward the late stage of the disease, musculoskeletal imaging manifestations typically associated with renal osteodystrophy and secondary hyperparathyroidism will develop, such as osteosclerosis, subperiosteal resorption, Brugger-jersey^ spine, and vascular/soft tissue calcifications (also seen in Fig. 1). Abnormal skeletal maturation and pathologic fractures with delayed healing can also be seen but are similarly nonspecific. Oxalate deposition in the subcutaneous and dermal tissues can cause skin necrosis/ulceration, and oxalate deposition in the myocardium, pericardium, ocular and vascular regions has also been described [4–9]. Skeletal findings more specific to primary hyperoxaluria may include irregular diametaphyseal transverse sclerotic bands and wide metaphyseal zones [5]. Lytic lesions can be seen in primary hyperoxaluria, which histopathologically represent foci of calcium oxalate deposition with a granulomatous foreign body histiocytic reaction, which appear essentially identical to brown tumors on The case presentation can be found at doi: 10.1007/s00256-015-2161-1.

Staging studies for evaluation of squamous cell carcinoma

Staging studies for evaluation of squamous cell carcinoma

Application of new imaging techniques for the evaluation of squamous cell carcinoma of the head and neck

The past several years have seen dramatic changes in imaging of the head and neck. Technical improvements in CT and MRI coupled with their widespread availability have made cross-sectional imaging an important adjunct in evaluation of patients with disease of the extracranial head and neck. The most recent advances in head and neck imaging are from new metabolic and functional imaging techniques. The intent of this report is to provide an update on the potential role of positron emission tomography, new MRI agents, and magnetic resonance spectroscopy for evaluating squamous cell carcinoma of the extracranial head and neck.

高周波口腔内探触子を用いた舌へん平上皮癌原発巣の超音波診断に関する研究

Recent progress in ultrasonography has enabled to provide high-resolution images of superfical regions. In this study, the usefulness of ultrasonography using a high frequency probe for squamous cell carcinoma of the tongue was evaluated. Thirty normal adult subjects were examined to study ultrasonographic findings of normal tongue. The pattern of the normal tongue showed clearly three different zones, corresponding to three layers; mucosal epithelium, proper lamina and tongue muscle. The mean and standard deviation of epithelium thickness was 2.1 +/- 0.6 mm. The ultrasonographic findings for tongue carcinoma in 104 patients were evaluated. The ultrasonographic pattern of tongue carcinoma showed a hypoechoic structure as compared with surrounding tongue muscle. Depth of invasion defined as the distance between normal mucosal surface and the deepest point in 59 patients was measured. The mean and standard deviation of depth of invasion measured by ultrasonography was 8.1 +/- 4.0 mm. The depth of invasion increased with T-stage. The difference of tumor depth between T1 and T2, or T1 and T3 was statistically significant (p < 0.001). A significant correlation (p < 0.001) was obtained between depth of invasion measured by ultrasonography and that measured by histological sections. In the group of patients with the tumor depth exceeding 8 mm (mean depth), the lymph node metastasis rate was 75.0% (15/20). In the group of patients with the depth of less than 8 mm, the incidence of metastasis was 29.8% (14/47). The difference between the two groups was statistically significant (p < 0.001). The 5-year survival rate calculated by the Kaplan-Meier method was 45.7% in patients with the depth exceeding 8 mm and was 87.5% in patients with the depth of less than 8 mm. The difference was statistically significant (p < 0.001). In conclusion, ultrasonography using a high-resolution probe was very useful for evaluation of squamous cell carcinoma of the tongue, and depth of invasion measured by ultrasonography could be a predictive factor for cervical lymph node metastasis and patient survival rate.

Diagnostic evaluation of squamous cell carcinoma metastatic to cervical lymph nodes from an unknown head and neck primary site

Diagnostic evaluation of squamous cell carcinoma metastatic to cervical lymph nodes from an unknown head and neck primary site